Cancer is a significant disease that threatens human life and health at present. The drugs development of cancer is severe, and it is very challenging to transform from lead compounds to clinical treatment. Drug repurposing, also known as drug retargeting, reanalysis, or redistribution, is an effective strategy to reduce the time and cost of bringing a drug to market. It is used to identify uses for approved or investigational drugs outside of their original indications. Compared with target-based lead compound discovery, drug repurposing has the advantages of high efficiency, short development cycle, low cost and low risk of failure. Many drug classes are currently being evaluated as candidates for cancer repurposing, including antidepressants, cardiovascular drugs, antipsychotics, and antibiotics. Therefore, this database can be used as an auxiliary tool for pharmacodynamic screening of clinically used drugs and pharmaceutical intermediates, systematic target analysis and mechanism research of clinically used drugs and pharmaceutical intermediates, so as to provide a research basis for the research and development of anti-tumor drugs, reduce the cost of developing cancer drugs, and improve the survival rate of cancer patients.