Cardiovascular Toxic Agents Database System (DTAD)
Project
name：Cardiovascular Toxic Agents Database System (DTAD)
BuildTime：2025-05-11
Mark
The cardiovascular system is a completely enclosed circulatory network composed of the heart and blood vessels (arteries, capillaries, and veins), which transports blood to organs and tissues throughout the body to fulfill essential physiological functions. Cardiovascular toxicity represents a severe adverse drug reaction and is considered the third most common drug-induced toxicity, following hepatotoxicity and nephrotoxicity. Clinically, it manifests as myocarditis, arrhythmias, hypertension, heart failure, and other conditions. The occurrence of such toxic effects can cause significant physiological harm to patients and may even be life-threatening, often necessitating therapeutic drug monitoring. The Cardiovascular Toxic Agents Database(DTAD) compiles 368 drugs with documented cardiovascular toxicity through extensive literature retrieval, including anticancer agents, antiarrhythmics, antibiotics, antipsychotics, and immunomodulators, among others. It systematically organizes fundamental drug information (e.g., generic names, molecular formulas, CAS registry numbers, structural details, and clinical applications) as well as toxicity-related data (e.g., mechanisms of toxicity, toxic manifestations, and incidence rates). The primary mechanisms of toxicity focus on oxidative stress, ion channel interference, and energy metabolism disruption. This database aims to enhance awareness of drug-induced cardiovascular toxicity, facilitate rapid assessment of potential cardiovascular risks associated with medications, and provide data support for drug development, clinical medication safety, and mechanistic toxicology research.
