Hematotoxicity refers to the harmful effects of drugs or other chemical substances on the blood system, primarily manifested as inhibition of bone marrow hematopoietic function and abnormal changes in the number or function of blood cells. The most prominent manifestation is drug-induced adverse reactions related to the blood system. Many drugs, such as certain antibiotics, antiepileptic drugs, and proton pump inhibitors, may lead to adverse reactions like thrombocytopenia, granulocytopenia, and aplastic anemia. The Hematotoxicity Database System is a powerful support for research on drugs and their hematotoxicity. It contains 334 drugs that can cause adverse reactions related to the blood system. The system records the chemical names, CAS numbers, drug types, clinical indications, and possible adverse reactions of these drugs and describes the hematotoxicity mechanisms of the drugs. These mechanisms are complex and include bone marrow suppression, immune-mediated destruction of blood cells, and metabolic interference, among others. The database is continuously updated and collects data. To some extent, it provides healthcare professionals with data resources on hematotoxicity drugs, helps them understand the relevant mechanisms, reduces the occurrence of drug-induced adverse reactions in the blood system, and serves as a warning to clinicians. When using these drugs, clinicians should closely monitor patients' blood indicators to achieve early detection and intervention, thereby ensuring patient safety.
