Fusobacterium nucleatum is a common Gram-negative anaerobic bacterium found in the oral cavity and the intestinal tract. It plays a significant role in the occurrence and development of malignant tumors such as colorectal cancer. The pathogenicity of Fusobacterium nucleatum is mainly achieved through various virulence factors, which play a crucial role in tumor occurrence, inflammatory response, and host immune evasion. Through systematic literature search and functional validation analysis, this database focuses on collecting data on the core virulence factors that have been clearly confirmed to be related to the pathogenicity, including 380 items. These items detail the sub-species classification, accession numbers, protein lengths, amino acid sequences, and related references of these virulence factors in different sub-species, presenting the sequence differences and conservation characteristics of virulence factors among different sub-species of Fusobacterium nucleatum. This provides a comprehensive data resource for in-depth understanding of the pathogenicity of Fusobacterium nucleatum, the functions of virulence factors, and the microbial-host interactions.
