Small molecule targeted prodrug technology demonstrates broad application prospects by enhancing drug selectivity, reducing toxicity, and improving pharmacokinetic properties. A small molecule targeted prodrug is a strategy that involves chemically modifying an active drug molecule into a derivative that can be activated under specific conditions in vivo, thereby improving the drug's targeting ability, stability, and bioavailability. This design can reduce side effects and enhance therapeutic efficacy, showing significant potential particularly in complex diseases such as cancer, viral infections, and inflammatory diseases. Small molecule prodrugs typically utilize enzymatic reactions, pH changes, or specific biomarkers to release the active ingredient in target tissues or cells, thereby achieving precise drug delivery. Based on relevant research from literature, this database aims to systematically collect the latest data on small molecule targeted prodrugs, with a focus on their design strategies, activation mechanisms, and therapeutic applications. The database includes information such as name, CAS registry number, molecular formula, molecular weight, structure (SMILES), IUPAC name, disease application, target, related patents, and references. This database is designed to provide support and assistance for the design, optimization, targeting evaluation, and clinical application of small molecule targeted prodrugs.
