Berberine, also known as berberine, is a quaternary ammonium alkaloid isolated from the traditional Chinese medicine Coptis and is widely distributed in the plant kingdom. Its pharmacological effects are diverse, not only can lower blood lipids, blood sugar, but also has a significant bacteriostatic effect, and is often used clinically for the treatment of gastrointestinal infections caused by sensitive pathogenic bacteria. As an alkaloid in a natural product, the significant advantages of berberine safety and low toxicity have also attracted widespread attention from scientists. In recent years, a large number of studies have confirmed that berberine derivatives have certain anti-tumor activity, and their combination with some chemotherapy drugs can achieve the effect of attenuating and increasing efficiency. Based on the current research progress of berberine derivatives and their anti-tumor activity, berberine derivatives have broad development and research prospects as potential anti-tumor active substances. In order to efficiently and conveniently track and understand the research progress of berberine derivatives anticancer activity, realize the depth of research content and multi-dimensional comparison, comprehensively organize and extract information from numerous research resources and results, and construct a berberine derivatives database to help promote the research of berberine derivatives in cancer treatment. This database includes the name, structure, molecular weight, molecular formula, target, cell line, tumor type, mechanism of action of berberine derivatives, and corresponding references, and supports multi-combination query of the above content. Therefore, the database will promote the new development of berberine derivatives in cancer treatment from multiple angles and comprehensively.
